Recent Developments of Achiral HPLC Methods in Pharmaceuticals Using Various Detection Modes
نویسنده
چکیده
High performance liquid chromatography (HPLC) is used extensively in the pharmaceutical industry due to the availability of fully automated systems, excellent quantitative precision, accuracy, broad linear dynamic range, and availability of a wide variety of column stationary phases. The technique is used in drug discovery, pre-clinical, and clinical development and factory finished product analysis. HPLC has greatly developed through the years in terms of convenience, speed, increased selection of column stationary phases, high sensitivity, applicability to a broad variety 1237 DOI: 10.1081/JLC-120030603 1082-6076 (Print); 1520-572X (Online) Copyright # 2004 by Marcel Dekker, Inc. www.dekker.com *Correspondence: Theresa K. Natishan, Merck & Co., Inc., Merck Research Laboratories, RY818-C215, P.O. Box 2000, Rahway, NJ 07065, USA; E-mail: [email protected]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES Vol. 27, Nos. 7–9, pp. 1237–1316, 2004
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